Lacteal derivative



Patented Apr. c,1--937 UNITED STATES PATEN oFF c-E 2,010,400 7 'mc'rnur. nmvanvn Forest H. Clickner, Chicago,

eese

Kraft-Phenix Ch III., a corporation of Delaware name on, m

No Drawing. Application are Is, 19:4,

3(Haims. (Cl. 20H) 1 My invention relates to lacteal derivatives and has to do more particularly with a new composition of matter which from whey,

and which composition is of great nutritive and therapeutic value.- It is especially terlal, said product obtained according to my,

invention is found to have an efliclency in calcium therapy superior to any material with which I am familiar. Furthermore, saidproduct is highly palatable and thus may be ingested either alone in the form of tablets, etc., or may be mixed with foodstufis, such as cheese, etc.

This application is a continuation in part of my co-pending application, Serial No. 692,314, filed October 5, 1933, wherein I have described the electrolysis of whey, in order to adjust the pH value thereof. The present invention may beconsidered an incident of said electrolysis.

Method I start with whey of an acid nature, the pH value thereof being approximately 4.3, the isoelectric point of casein. The acid present in the whey may be lactic acidformed by natural fer mentation or it may be a foreign acid, such as, say, hydrochloric acid introduced for the purpose of separating the casein from milk, or for other purposes, as set forth in my said co-pending application Serial No. 692,314. If the acidity of the whey is not originally at the desired pH value, it may be adjusted to about 4.3 by obvious means.

The whey of such pH value is run through an electrolytic cell, preferably in a continuous stream. Said cell may be of any well-known or other suitable type, but I prefer a cell having an outer cylindrical shell of iron, serving as a cathode, said shell being connected in a suitable electrical circuit and having an inlet at the bottom into which the whey is introduced. Whey is forced upwardly through the cell and overflows I into a funnel-like or other suitable receptacle from which it is withdrawn from time to time or preferably continuously. Within said metallic 5 receptacle, and preferably concentric therewith,

may be readily obtained at the top, whence it drops, in a broken stream,

is a cylindrical porous'cup formed of aluminum oxide (A1:O;) or ceramic ware or other suitable semi-permeable material, said cup being closed at the. bottom and open at the top. Disposed cen- V trally within said cup is a carbon-anode, which may be connected to any convenient source of current and in the circuit with said cathode.

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The porous cup is kept filled wlthsodium chloride solution, the concentration of. which is maintained at such a point as will be .sufilcient to modify the pH value of the whey passing through the cell tosuch an extent that the whey leaving the cell will have a pH value within the approximate range of 5.5 to 6. I have found the optimum pH value to be about 5.7, which yields a product highin vitamin G content. However, if the vitamin G value is not of particular importance, the pH adjustment need not be so restricted. The preferred concentration of salt which is desired to be maintained within the porous cu ls'approximately- 15 per cent NaCl.

The electrolysis of the whey flowing through .the cell results not only in modifying the pH value thereof, as just described, but also inv precipitating substantially all of the calcium present in the whey. This is'the substance which is especially desirable in my final product. In addition to the calcium, there is also precipitated approximately 20 per cent of the phosphorus present in the whey. As stated above, I am not able to state in precisely what chemical form these substances will be precipitated, although it can be said that they are probably in the form of inorganic salts. v

The whey withdrawn fromthe cell is preferably conducted directly to an Olivertype of filter or similar apparatus capable of filtering out the material precipitated as a result of the electrolytic operation. The filter separates said precipitate from theaqueous fluid and the latter may be conducted to suitable apparatus to be converted to whey powder, in accordance with any well-known process; for example, the process demay be as high as possible in the ultimate prodnot, the precipitate is preferably washed with water to remove the lactose therefrom, which is usually present in the proportion of about 25 per cent by weight of the original precipitate, and

said wash liquid containing the lactose may be added to the filtrate to be dried, as described above.

The valuable residue may be removed from dried product is now ready for consumption. It

- etc. It willbe found that the improved desired, it may becompressed in the form of pellets or tablets or it may be added as a powder to various articles of food, such as cream cheese, product blends well in flavor with most dairy products, and has a pleasing taste.

A typical example of my improved product has approximately the following composition:

Percent Calcium (Ca) V 18 1 Phosphorus (P2) 6.3 Protein (as lactalbumin) ..-20

An important application of my invention is in the treatment of various diseases in which calcium metabolism is of great importance, such as migraine, allergic diseases, such as asthma, thyroid disorders, and various other calcium-deiiciency diseases. In the treatment of such diseases it has been customary heretofore to administer calcium gluconate- 'However, a disadvantage of this materialis that it is not equally advantageous for all persons; the therapeutic efficiency apparently varies with different individuals. However, with my improved product it is found that the calcium is in extremely highly assimilable form and may be used with very great and substantially equal efilciency with all individuals. Furthermore, my improved product contains at least twice as much calcium as calcium gluconate and has at least twice the therapeutic efilcieucy.

It is believed that the calcium in my improved compound is in the same chemical form as in natural milk. Howeve five grams of my improved dry powder contains a quantity of calcium equal to that present in one quart of milk and, furthermore, is much, more highly assimilable, so that the calcium efllciency of five grams of my improved product is considerably greater than that of a quart of milk. This may be explained by pointing out that the assimilability of the calcium in milk is interfered with by the other.

substances present in the milk. However, in my improved product the calcium may be substantially all metabolized, so that it will have the utmost eilect when administered for calcium deficiency a,ove,4oo

ent in my product into the blood stream is extremely rapid.

It is also obvious that the phosphorus content of my improved product, which is in similar form to that of milk, is also of considerable value. Thus, recent researches have revealed that the phosphorus present in milk is of considerable therapeutic value in the human body in maintaining the health and sexual potency of an individual, and my improved product is of value in this connection.

various modifications coming within the spirit of my invention will doubtless suggest themselves to those skilled in the art and, hence, I do not wish to be limited to the specific embodiments described above but. intend that the scope of my invention shall be determined from the appended claims, which are to be construed as broadly as the state of the art will permit.

I claim as my invention:

1. A continuous method of precipitating a therapeutic composition containing a substantial proportion of assimilable calcium and phosphorus salts which comprises passing an acid whey solution having a pH value of about 4.3 through a cathode compartment of an electrolytic cell having the anode thereof bathed in a salt solution of a highly ionizable alkali metal and separated from said cathode compartment by a semipermeable material so that the pH value of the whey solution on leaving said compartment is about 5.'l.-

2. A continuous method of precipitating a therapeutic salt composition containing about 18 per cent calcium and about 6 per cent phosphorus which comprises passing an acid whey solution having a pH value of about 4.3 through a cathode compartment of an electrolytic cell having the anode bathed in an aqueous solution of sodium chloride and separated from said cathode compartment by a porous ceramic cup, the rate of fiow of said whey solution being so regulated that the pH value thereof on leaving the cell is about 5.7.

3. A continuous method of precipitating a therapeutic composition containing a substantial proportion of assimilable calcium and phosphorus salts which comprises passing an acid whey solution having a pH value of about 4.3 through a cathode compartment of an electrolytic cell having the anode thereof bathed in a sodium chloride solution and separated from said cathode compartment by a porous aluminum oxide receptacle the rate of flow of said whey solution being so regulated that the pH value thereof on leaving the cell is about 5.7.

. FOREST H. CLICKNER. 

